myherbclinic
DNA Wellness Report
Naturopathic Summary
Your DNA
Wellness Report
A Personalised Naturopathic Genetic Summary
| Prepared for | [Client Name] |
| Date | [Date] |
| Platform | AncestryDNA / 23andMe |
| Report by | Krystle Holzberger — Clinical Naturopath |
Welcome to Your DNA Wellness Report
Congratulations on taking this important step toward understanding yourself at the deepest level. This report is the result of a detailed analysis of your raw genetic data, interpreted through the lens of naturopathic medicine.
This document is your naturopathic review and personalised summary. You will also have received the full raw genetic analysis report. This summary has been prepared by Krystle Holzberger, Clinical Naturopath, to interpret the most clinically relevant findings and provide practical recommendations you can act on.
I am Krystle Holzberger, a degree-qualified Clinical Naturopath holding a Bachelor of Health Science (Naturopathy), completed in 2019. My connection to this work goes beyond my qualifications — for years I lived with symptoms that standard testing repeatedly failed to explain. My own DNA analysis finally provided answers, revealing compound heterozygous MTHFR alongside SNPs that significantly impair B12 metabolism and Vitamin D utilisation.
Warmly,
Krystle Holzberger
BHSc (Naturopathy) — Clinical Naturopath — My Herb Clinic
Important: For educational and wellness purposes only.
Does not constitute medical diagnosis or replace advice from your treating practitioner.
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HOW TO READ THIS REPORT
This summary accompanies the full Genotype Data Report. Together they form your complete DNA Wellness Report.
Colour coding in the genotype report:
| Yellow — One copy of effect allele (heterozygous) |
| Gold — Two copies of effect allele (homozygous) |
| None / -- — Variant not tested or not carried |
What is covered:
1.MTHFR and Methylation
Folate metabolism, B12, methylation
2.Vitamin B12 and Folate
Transport, binding, conversion
3.Vitamin D
Synthesis, transport, receptor
4.Coeliac and Gluten Sensitivity
HLA types and risk factors
5.Iron and Haemochromatosis
Iron accumulation and HFE genes
6.Heart Health and Clotting
Cardiovascular risk, clotting, cholesterol
7.Autoimmune Tendency
RA, thyroid, lupus
8.Inflammation
TNF-alpha, interleukins, pathways
9.Histamine and DAO Enzyme
Histamine breakdown factors
10.Your Genetic Superpowers
Protective variants and strengths
11.Diet, Lifestyle and Supplements
Naturopathic recommendations
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1. MTHFR AND METHYLATION
One of the most significant findings in your profile. You carry variants in both main MTHFR positions — making you compound heterozygous MTHFR.
| Gene | RS ID | Geno. | Significance |
|---|
| MTHFR | rs1801133 | AG | C677T — 40-70% enzyme reduction |
| MTHFR | rs1801131 | TG | A1298C — 10-20% enzyme reduction |
Supplement considerations:
• Methylfolate (5-MTHF) — not folic acid
• Methylcobalamin B12 (not cyanocobalamin)
• Riboflavin (B2) supports MTHFR function
• Check homocysteine via blood test
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3. VITAMIN D
7 matched variants across synthesis enzymes, binding protein (GC), and receptor (VDR). Standard doses are often insufficient with this combination.
| Gene | RS ID | Geno. | Significance |
|---|
| GC | rs7041 | AA | Lower Vit D — binding protein (homozygous) |
| GC | rs1155563 | TC | Significantly lower Vitamin D |
| GC | rs2282679 | TG | Lower Vitamin D levels |
| VDR | rs1544410 | TC | Lower Vit D — receptor (Bsml) |
| CYP2R1 | rs2060793 | AG | Lower Vit D — conversion enzyme |
| CYP2R1 | rs10741657 | AG | More likely Vitamin D insufficient |
Supplement considerations:
• Test 25-OH Vitamin D — aim 100-150 nmol/L
• 3,000-5,000 IU D3 daily; retest after 3 months
• Always take D3 with K2 (MK-7)
• Magnesium essential for D conversion
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6. HEART HEALTH AND CLOTTING
Multiple matched variants across blood pressure, clotting pathways, fibrinogen, and cholesterol. ACE deletion is homozygous — a high-priority finding.
| Gene | RS ID | Geno. | Significance |
|---|
| ACE | rs4343 | GG | ACE deletion — increased BP and CAD risk |
| AGTR1 | rs5186 | AC | Increased blood pressure risk |
| FGB | rs1800787 | TC | Increased fibrinogen — stroke risk |
| FGG | rs2066865 | AG | Increased fibrinogen — DVT risk |
| ITGB3 | rs5918 | TC | PIA1/A2 — heart disease risk |
| APOB | rs693 | AG | Higher LDL and total cholesterol |
Cardiovascular priorities:
• Request Lp(a) — NOT in standard cholesterol panels
• Omega-3 EPA/DHA 2-3g daily
• Mediterranean-style diet as foundation
• Monitor blood pressure regularly
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10. YOUR GENETIC SUPERPOWERS
Your DNA is not all risk — there are genuinely impressive protective variants in your profile worth acknowledging.
| Gene | RS ID | Geno. | Significance |
|---|
| IL1B | rs16944 | GG | Less than half H3N2 influenza risk |
| IL28 | rs8099917 | TG | Half the H3N2 influenza risk |
| CCR5 | rs333 | DI | Reduced HIV disease progression |
| TAS2R38 | rs713598 | CG | Bitter taste — cruciferous vegetables |
| FUT2 | rs601338 | AG | Some norovirus resistance |
Your standout strengths:
• Strong flu resistance — IL1B (GG) and IL28 (TG)
• Bitter taste receptor — guided toward protective foods
• CCR5 — reduced HIV disease progression
• FUT2 — some norovirus resistance
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11. DIET, LIFESTYLE AND SUPPLEMENTS
Diet Priorities
Mediterranean-style whole foods diet as foundation
Minimise synthetic folic acid — impairs MTHFR pathways
Gluten investigation before any elimination
Low-histamine trial if symptomatic
Minimise alcohol — impairs methylation, raises histamine
Key Supplements
Methylfolate (5-MTHF) — avoid folic acid entirely
Methylcobalamin B12 — sublingual preferred
Vitamin D3 with K2 — test first, supplement to target
Magnesium glycinate — essential for multiple pathways
Omega-3 EPA/DHA 2-3g daily
Health Monitoring
Homocysteine, MMA, 25-OH Vitamin D, Lp(a), fibrinogen, CRP
Full thyroid panel including Anti-TPO and Anti-TG
Annual iron studies: ferritin, serum iron, transferrin saturation
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Important Information and Disclaimer
This DNA Wellness Report has been prepared by Krystle Holzberger, BHSc (Naturopathy), in her capacity as a qualified Clinical Naturopath at My Herb Clinic. It is intended for health education and wellness purposes only.
This report does not constitute medical diagnosis. Genetic variants indicate tendencies — they do not determine outcomes.
Please discuss findings with your treating medical practitioner before making changes to medications or treatment.
Prepared by My Herb Clinic — Krystle Holzberger, Clinical Naturopath
myherbclinic.com.au — naturopath@myherbclinic.com.au
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